Leukocytoclastic vasculitis (palpable purpura)
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You are here: Home » Dermatology Notes » Leukocytoclastic vasculitis (palpable purpura)
Purpuric papules most often on the lower extremities usually lasting several weeks. Commonly associated with fever, arthralgias and other systemic symptoms including renal involvement. May be idiopathic or associated with a variety of triggering factors (medications, infections, connective tissue disorders).
Diagnosis
Clinical suspicion confirmed by biopsy.
Pathology
Immune complex deposition in the cutaneous vessels leading to vascular destruction and extravasation of RBC’s.
Principles of Therapy
If possible, treatment of the precipitating event or disorder. A variety of medications can be helpful: NSAIDS, Dapsone, Colchicine or Prednisone.
Tags: purpura, vasculitis
Category: Dermatology Notes
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