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Developmental Overview of Eye!
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27.2.08
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Developmental Genes
Pax6 active in epithelial and mesenchymal cells during ocular development (at different times)
Pitx2 homeobox gene: in neural crest required for optic stalk and ocular anterior segment development.
Rx paired-like homeobox gene
Hh Hedgehog
EGF Epidermal Growth Factor receptor signaling pathway: roles in cell proliferation, survival and differentiation.
FGF Fibroblast growth factors: retinal cell proliferation, retinal ganglion cell axon guidance/target recognition, craniofacial patterning and lens induction.
Components of Eye Formation
surface ectoderm
*lens placode
--->lens pit
--->lens vesicle
--->lens fibres
--->lens capsule
--->embryonic/fetal nucleus
*eyelid(inner canthus)
--->conjunctival sac
--->conjunctival sac (upper & lower recesses)
--->tear ducts
*optic eminence
--->corneal ectoderm
--->cornea (+neural crest)
neural crest
*perioptic mesenchyme
--->stroma
--->ectoderm (endothelium of anterior chamber)
--->Descemer's membrane (from stroma and ectoderm)
--->cornea (+surface ectoderm)
*scleral mesenchyme
--->sclera
neural ectoderm
optic placode & optic sulcus
optic pit
optic vesicle (primary)
optic vesicle (secondary)
future pigment layer
pigment layer
future neural layer
neural layer
nerve fibre layer
inner nuclear layer
intermediate nuclear layer
outer nuclear layer
ciliary body (from retinal periphery)
iris (pupil)
optic stalk
optic nerve (II) optic chiasma
optic disc
choroid/fetal fissure
blood vessels
internal carotid artery
opthalmic artery
hyaloid vascular plexus
choroidal vessels
tunica vasculosa lentis
hyaloid artery (central artery of retina)
vasa hyaloidea propria
perioptic (orbital) mesoderm
extrinsic ocular muscles PMM
extrinisic ocular muscles
hyaloid cavity
anterior chamber
vitreous humour
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Anatomy Notes
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