Myocarditis

• Young people without heart disease

• Usually viral (coxsackievirus, enterovirus, adenovirus)
• Parasites - Trypanosoma (Chagas disease, S America), toxoplasmosis, trichonosis
• Rarer – CMV, HIV, fastidious bacteria
• Hypersensitivity myocarditis: Anticancer drugs, SLE, inflammatory myopathies, cardiac allograft rejection
• Sarcoidosis

• Inflammatory process of the myocardium that causes biventricular failure Diffuse myocardial degeneration and necrosis with inflammatory infiltrate
• T cells are cytotoxic to infected myocytes
• Flabby, pale, hemorrhagic, mottled, dilated heart
• Abscesses with PMN infiltrate if bacterial
• Edematous with infiltrate of lymphs and monos if viral
• Giant cell Myocarditis – presence of giant cells; progresses rapidly
• Causes severe CHF, symptoms of dilated cardiomyopathy, and lethal Arrythmias
• If HS Myocarditis, will see eosinophils

Category: Medicine Notes