Isoproterenol
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Activates ß adrenergic receptors (both ß1 - and ß2 -receptor subtypes)
Has limited action at a adrenergic receptors
i.v. influsion of isoproterenol results in a slight decrease in mean blood pressure with a marked drop in diastolic pressure.
ß2 - adrenergic receptor-mediated reduction in peripheral resistance (reflected in the diastolic pressure effects) is primarily due to vasodilation of skeletal muscle vasculature. Renal and mesenteric vascular beds are also dilated.
Activation of cardiac ß1 - adrenergic receptors: increased contractility and heart rate.
Activation of ß2 - adrenergic receptors: Bronchial and GI smooth muscle relaxation.
Category: Pharmacology Notes
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