Controlled Release Drug Delivery Systems

on 19.1.08 with 0 comments



  • Designed to release drugs slowly for more prolonged drug release and sustained action

Advantages

  • Extended and sustained duration of Action
  • Reduced frequency of Drug Administration
  • Relatively stable plasma concentrations, thus reduced potential adverse effects caused by sudden peaks and troughs.
  • Improved patient compliance
  • Potential lower daily costs as fewer dosage units are required.

Drugs Suited

  • Drugs with fairly rapid rate of absorption and excretion.
  • Having relatively small doses
  • Drugs that are uniformly absorbed from the Gastrointestinal tract.
  • Drugs used in treatment of chronic conditions rather than acute conditions.


Methods
  1. Coated beads/granules or micro-encapsulated drug (Aspirin)
  2. Embedding a drug into a slowly eroding matrix.
  3. Embedding drug into an inert plastic matrix
  4. Hydrocolloid System
    1. For hydrodynamically balanced drug delivery system (HBS)
      1. Slow release form of diazepam
    2. Osmotic Pumps
    3. Occuserts
  5. Subdermal implants
    1. Oldest form of controlled release delivery systems for hormones.

Category: Pharmacology Notes

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