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- Designed to release drugs slowly for more prolonged drug release and sustained action
Advantages- Extended and sustained duration of Action
- Reduced frequency of Drug Administration
- Relatively stable plasma concentrations, thus reduced potential adverse effects caused by sudden peaks and troughs.
- Improved patient compliance
- Potential lower daily costs as fewer dosage units are required.
Drugs Suited- Drugs with fairly rapid rate of absorption and excretion.
- Having relatively small doses
- Drugs that are uniformly absorbed from the Gastrointestinal tract.
- Drugs used in treatment of chronic conditions rather than acute conditions.
Methods
- Coated beads/granules or micro-encapsulated drug (Aspirin)
- Embedding a drug into a slowly eroding matrix.
- Embedding drug into an inert plastic matrix
- Hydrocolloid System
- For hydrodynamically balanced drug delivery system (HBS)
- Slow release form of diazepam
- Osmotic Pumps
- Occuserts
- Subdermal implants
- Oldest form of controlled release delivery systems for hormones.
Category:
Pharmacology Notes
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