HAEMOCHROMATOSIS (Robbins pp 873)
on
2.12.07
with
0 comments
You are here: Home » Pathology Notes » HAEMOCHROMATOSIS (Robbins pp 873)
- This disease is characterized by excess accumulation of iron in the body.
- The majority of this goes to the liver. The excess accumulation occurs as a result of excess absorption from the gut.
- This occurs due to a genetic defect or acquired defect. The genetic defect is in the gene which encodes a protein that is responsible for influencing iron absorption. The acquired defect is when patients take in excess iron by various sources (i.e.: transfusions etc).
- Iron is directly toxic to hepatocytes: it stimulates collagen formation, and its directly injuries the DNA.
- If the cell is not fatally injured, then reversing the effects will result in recovery, however – not otherwise.
Category: Pathology Notes
Subscribe to:
Post Comments (Atom)
POST COMMENT
0 comments:
Post a Comment