MISCELLAENOUS LESIONS OF THE GALL BLADDER (Robbins pp 895)

Cholesterolosis: this occurs when the liver produces excess cholesterol, and this is esterified in the gall bladder producing yellow speckles on the mucosa  strawberry gallbladder.

MISCELLANEOUS LESIONS OF THE BILE DUCTS (Robbins pp 878)

Intrahepatic bile ducts

Primary biliary cirrhosis: Refer to lecture “acuteandchronicliverconditions”. Morphology: 1) florid duct lesions: this lesion occurs pre-cirrhotically, where the interlobular bile ducts are destroyed by granulomatous inflammation, 2) ductular proliferation: proximal to the florid duct lesion, there is ductular proliferation with periductular hepatic parenchyma destruction, 3) fibrosis: slowly the portal areas become fibrotic from the inflammation, 4) cirrhosis: the fibrosis moves inward towards central veins, and liver becomes cirrhotic.

Extrahepatic bile ducts

Primary sclerosing cholangitis: This is when there is chronic inflammation of the extra hepatic biliary tree, leading to fibrosis and stricture formation. You will see a classic beaded appearance in barium radiographs. Patients with this seem to also have ulcerative colitis in 70% of cases.

Category: Pathology Notes