Genetics Via Mnemonics

on 6.7.07 with 0 comments



1. DNA: Z vs. B form: which is inactive
ZZZZ is sleeping (inactive). B form is therefore active DNA.

2. Hurler Syndrome features HURLER'S:
  • Hepatospenomegaly
  • Ugly facies
  • Recessive (AR inheritance)
  • L-iduronidase deficiency (alpha)
  • Eyes clouded
  • Retarded Short/
  • Stubby fingers
3. Blots: function of Southern vs. Northern vs. Western
SN0W DR0P:
Match up the 1st word letter with 2nd word letter:
  • Southern=DNA
  • Northern=RNA
  • Western=Protein
· The 0's in snow drop are zeros, since there is no Eastern blot.

4. Marfan syndrome features MARFAN:

  • Mitral valve prolapse
  • Aortic Aneurysm
  • Retinal detachment
  • Fibrillin
  • Arachnodactyly
  • Negative Nitroprusside test (differentiates from homocystinuria)
5. Mitochondrial DNA (mt DNA) properties
"mt DNA".
mt stands for:
Maternal Transfer
Mutates Tremendously (high mutation rate)

6. Imprinting diseases: Prader-Willi and Angelman

Pray to an Angel:

Prader-Willi and Angelman are the 2 classic imprinting diseases. · Which disease results, depends on whether 15q deletion is maternal or paternal. Keep them straight by: Paternal is Prader-Willi.

7. Chromosome 15 diseases
Chromosome 15 has its own MAP:
Marfan syndrome
Angelman syndrome
Prader-Willi syndrome


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Category: Mnemonics

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