Carcinogenesis: Oncogenes and cancer

on 18.7.07 with 0 comments



General

  1. cancer causing genes—ONCOGENES—are derived from proto-oncogenes

    1. proto-oncogenes are normal cellular genes which promote

      1. normal growth and development

    2. discovered in animals infected with cancer-causing viruses

  2. DNA of spontaneously arising cancers contain oncogenic sequences or oncogenes

  3. Protooncogenes become oncogenic by

    1. retroviral transduction—V-onc

    2. influences that also behavior in situ—c-onc (cellular oncogene)

  • Protein products of oncogenes

    1. general

      1. oncoproteins

        1. proteins encoded by oncogenes

        2. devoid of regulatory elements

          1. production not dependent of growth factors/external signals

        3. altered versions of their normal counterparts


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    Category: Pathology Notes

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