Carcinogenesis: Genes that regulate apoptosis

on 18.7.07 with 0 comments



  1. Bcl-2

    1. Prototype of ANTI-APOPTOSIS gene

    2. Located on chromosome #18

    3. Activated by translocation to Ig heavy chain locus on chromosome #14 in majority of follicular B cell lymphomas

    4. Over-expressed bcl-2 protects lymphocytes from undergoing apoptosis

      1. results in reduced cell death—slow growing

  2. bax

    1. opposes bcl-2 action and accelerates cell death

    2. relative levels of bax/bcl-2 regulate cell survival

  3. p53

    1. triggers apoptosis if cells are exposed to mutagens and cannot repair DNA

    2. increases transcription of bax

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Category: Pathology Notes

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