Protein synthesis Inhibitors: 2

Broad-spectrum antibiotics – Lincosamides

Clindamycin & Clindamycin phosphate

MOA: Lincosamides bind exclusively to the 50S subunit and either inhibit the peptidyl transferase reaction and/or prevent translocation of tRNA from the A site to the donor site.

Spectrum: Mostly G(+), some G(-); clindamycin phosphate targets G(+,-) AND anaerobes (drug of choice).

Resistance: Erythromycin-resistant organisms are likely to be resistant to clindamycin.

Pharmacokinetics: Well absorbed in the GI tract. Metabolized by liver. Excreted by kidney and in bile.

Toxicity: Most common problem is severe and persistent diarrhea (pseudomembraneous colitis may occur).

Therapeutic place: Clindamycin and clindamycin phosphate are effective against anaerobes (specifically B. fragilis) and are alternate drugs for pneumococci, streptococci, and staphylococci.

Category: Pharmacology Notes