DRUGS ON THE EYE

1. Deliver the agent to the site desired
2. In the form that is required
3. In the proper vehicle
4. At the right concentration
5. Ensure it only acts where it is intended

• Only in dermatology and opthalmology can these principles be adhered to properly
• The eye, like the skin, is an exposed structure, therefore, it is open to the elements and it is possible to apply drugs directly to the surface via drops or ointments.

• Cornea
• Iris
• Conjunctiva
• Ciliary body

• The drug needs to be able to penetrate the cornea
• It needs to be in sufficient concentration as the fluid in the eye (aqueous and vitreous humor) will dilute the drug
• When applying something to the eye, the natural protective response is to produce tears. This is another factor which tends to dilute the drug.

Category: Pharmacology Notes