Class IV: Calcium Channel Blockers
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- These drugs block the inward calcium current and therefore slow conduction through the AV node and decrease the slow of phase 4 depolarization.
- Calcium channel blockers are especially active at vascular smooth muscle and at the heart.
- Verapamil (main action on the heart)
- Nifedipine (main action on vascular smooth muscle (anti-hypertensive effect))
- Diltiazem (action on both the heart and vascular smooth muscle)
Category: Pharmacology Notes
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