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Laboratory test
| Purpose or interpretation
| | Routine tests (including complete blood cell count, liver enzymes, creatinine, urinalysis) | Evaluate for hematologic, renal and other organ involvement | | Blood cultures | Rule out infection | | Erythrocyte sedimentation rate | High value suggests inflammatory disease | | C-reactive protein | High value suggests inflammatory disease | | Rheumatoid factor | Very high titers in rheumatoid arthritis, Sjögren's syndrome and cryoglobulinemia-associated vasculitis | | Antinuclear antibody | Screen for SLE and Sjögren's syndrome | | Complements (C3, C4, CH50) | Low complement levels suggest consumption by immune complexes, which are commonly found in SLE and cryoglobulinemia | | Cryoglobulins | Must be present to diagnose mixed essential cryoglobulinemia but can be found in any primary or secondary vasculitis | | ANCA | Cytoplasmic ANCA pattern specific for Wegener's granulomatosis; perinuclear ANCA pattern may occur in other vasculitides | | Creatine phosphokinase | Elevation suggests myositis, which can occur in many vasculitis syndromes | | RPR/VDRL | Rule out syphilis | | Serum protein electrophoresis | Evaluate for plasma cell dyscrasias | | Hepatitis B and C serology | Rule out hepatitis B or hepatitis C infection | | HIV | Rule out HIV infection | | Anti-glomerular basement membrane | Rule out Goodpasture's syndrome, which can mimic vasculitis and cause pulmonary hemorrhage and glomerulonephritis |
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| SLE = systemic lupus erythematosus; ANCA = anti-neutrophil cytoplasmic antibodies; RPR = rapid plasmin reagin; HIV = human immunodeficiency virus. |
Category:
Pathology Notes
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