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- Generation by gain of HCO3 and maintained by abnormal renal HCO3 absorption.
- This is almost always secondary to volume contraction (low Cl in urine, responsive to NaCl, maintained at proximal tubule)
- Vomiting: net loss of H+ and gain of HCO3.
- Diuretics: ECFV depletion
- Chronic diarrhea: ECFV depletion
- Profound hypokalemia
- Renal failure: if we cannot filter HCO3 we cannot excrete it.
- Mineralocorticoid excess: increased H secretion, hypokalemia (Na/K exchanger), saline resistant).
Category:
Biochemistry Notes
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