Drug Toxicities

on 13.2.06 with 0 comments



Drug Toxicities


Agranulocytosis

- Clozapine

Aplastic Anemia

- Chloramphenicol

- NSAIDs

- Benzene

Atropine-like Side Effects

- Tricyclics

Cardiotoxicity

- Doxorubicin

- Daunorubicin

Cartilage Damage in children

- Fluoroquinolones (Ciprofloxacin & Norfloxacin)

Cinchonism

- Quinidine

Cough

- ACE Inhibitors

Diabetes Insipidus

- Lithium

Disulfiram-like effect

- Metronidazole

- Sulfonylureas (1st generation)

Extrapyramidal Side Effects

- Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)

Fanconi’s Syndrome

- Tetracycline

Fatal Hepatotoxicity (necrosis)

- Valproic Acid
- Halothane
- Acetaminophen

Gingival Hyperplasia

- Phenytoin

Gray Baby Syndrome

- Chloramphenicol

Gynecomastia

- Cimetidine
- Azoles
- Spironolactone
- Digitalis

Hemolytic Anemia in G6PD-deficiency

- Sulfonamides
- Isoniazid
- Aspirin
- Ibuprofen
- Primaquine

Hepatitis

- Isoniazid

Hot Flashes, Flushing

- Niacin
- Tamoxifen
- Ca++ Channel Blockers

Induce CP450

- Barbiturates

- Phenytoin

- Carbamazepine - Rifampin

Inhibit CP450

- Cimetidine

- Ketoconazole

Interstitial Nephritis

- Methicillin
- NSAIDs (except Aspirin)
- Furosemide
- Sulfonamides

Monday Disease

- Nitroglycerin Industrial exposure  tolerance during week  loss of tolerance during weekend  headache, tach, dizziness upon re-exposure

Orange Body Fluids

- Rifampin

Osteoporosis

- Heparin
- Corticosteroids

Positive Coombs’ Test

- Methyldopa

Pulmonary Fibrosis

- Bleomycin

- Amiodarone

Red Man Syndrome

- Vancomycin

Severe HTN with Tyramine

- MAOIs

SLE-like Syndrome

- Procainamide

- Hydralazine

Tardive Dyskinesia

- Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)

Tinnitus

- Aspirin

- Quinidine


Category: Pharmacology Notes

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