Erythrocytes
on
5.7.05
with
0 comments
You are here: Home » Pathology Notes » Erythrocytes
- 7.5 micron diameter; 2.0 micron thick
- biconcave disk shape; ideal for gas exchange spectrin - elastic protein; allows shape change
- mature cells are anucleate (no nucleus)
- very few organelles; mainly a hemoglobin carrier. Hemoglobin - 33% of cell mass; carries oxygen
- no mitochondria; only anaerobic respiration
- ratio erythrocytes:leukocytes = 800:1
- red blood cell count: # cells per cubic millimeter
- normal male count - 5.1 to 5.8 million
- normal female count - 4.3 to 5.2 million
B. Functions (oxygen & carbon dioxide transport)
1. Hemoglobin - large molecules with globin and hemes
a. globin - complex protein with 4 polypeptides (2 alpha and 2 beta polypeptides)
b. heme group - IRON containing pigment part of hemoglobin to which oxygen binds
- each polypeptide has one heme group;each heme carries on O2
- infants 14-20 grams/100 ml
- adult female 12-16 grams/100 ml
- adult male 13-18 grams/100 ml
2. States of hemoglobin
a. oxyhemoglobin - when oxygen is bound to IRON
b. deoxyhemoglobin - no oxygen bound to IRON
c. carbaminohemoglobin - when carbon dioxide bound (to polypeptide chain)
Tags: Erythrocytes, Blood, Hemoglobin
Category: Pathology Notes
Subscribe to:
Post Comments (Atom)
POST COMMENT
0 comments:
Post a Comment