Classification of Immune Reactions to Penicillin
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*Type I: IgE on mast cells combines with penicillin antigen:
Immediate (< 1h) urticaria (hives), anaphylaxis (bronchospasm, hypotension,
cardiovascular collapse).
Accelerated (1-72h) usually urticaria
Type II: cytotoxic antibody, e.g. Coombs positive hemolytic anemia
Late reactions, >72h
Type III: immune complex (serum sickness, late reaction)
Type IV: cell mediated (contact dermatitis, late reaction)
*Type I is the type that we worry about, could be life threatening
Category: Pharmacology Notes
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