Creatinine

• ATP + creatin = ADP + creatinine

• 1.5 mg/dl per deciliter normal - panic is 10mg/dl

• Once converted into creatinine you cannot reabsorb it

• 1/2 renal capacity used on max capacity (there are two kidneys)

  • Disease can be masked because of this

• Creatinine clearance test

  • Used for GFR testing

  • Increased blood levels of creatinine - possibly have renal failure

• Oligouria

  • 500 ml lost a day

• Anuria

  • 100ml per 24 hrs or less

• Unusual high elevation in a pt with increased growth hormone could have creatinine

  • Whether acromegaly or gigantism

• Norm is .5 - 1.5 mg/dl

  • If low expect a muscle wasting disease

• Creatinine is a more accurate GFR unlike urea which can leak back.

Category: Nephrology Notes