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|         Factor  |              Blastic Metastases  |              Paget’s Disease  |              Hodgkin’s Disease  |    
|         Age (years)  |              >45  |              >50  |              20-40  |    
|         Increased density  |              +++  |              +++  |              +++  |    
|         Expansion  |              ----  |              +++  |                         |    
|         Anterior Scalloping  |              ----  |              ----  |              +++  |    
|         Acid phosphatase  |              +++  |              ----  |              ----  |    
|         Alkaline phosphataes  |              ++  |              +++  |              ++  |    
   
 
   
 
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Pelvis includes protrusio acetabuli with Kohler’s teardrop and thickening of pelvic brim
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Long bones: the tibia is the m/c lytic site
 
   
 
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Complications
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Deformity of bone include: Shepherd’ crook deformity of the proximal femur (coxa vara), Saber shin (ant. Tibial bowing), Protrusio acetabuli.
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Cranial nerve neuropathies b/c foramen get smaller.
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Linked to increased wear and tear, early DJD
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Increased alkaline phospatase (up to 20x normal)
 
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Category: Orthopedics Notes



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