Nucleotide-analogues

Tenofovir (Viread®). Tenofovir disoproxil fumarate (Viread®) is administered as a 300 mg tablet once a day, preferably with a meal. It has less side-effects than most other drugs. Nucleotide analogues closely resemble nucleoside analogues such as Retrovir® or Epivir®. The only difference is that nucleotide analogues are chemically preactivated and thus have to undergo less biochemical processing in the body before becoming active. Tenofovir is studied as a preventive once-per-day pill for high-risk groups such as prostitutes. If the results of these studies would show a positive preventive effect, it would be important not to loose sight of condom-use as a preventive stategy.