HIV Clinical stage 4

• HIV wasting syndrome (weight loss >10% body weight plus unexplained chronic diarrhoea or chronic weakness and unexplained prolonged fever (> 1 month).

• Pneumocystis carinii pneumonia

• Toxoplasmosis of the brain

• Cryptosporidiosis with diarrhoea for > 1 month

• Extrapulmonary cryptococcosis

• CMV infection of an organ other than liver, spleen or lymph nodes

• Herpes simplex virus infection, mucocutaneous > 1 month, or visceral (any duration)

• Progressive multifocal leukoencephalopathy

• Any disseminated endemic mycosis

• Candidiasis of the oesophagus, trachea, bronchi or lungs

• Disseminated atypical mycobacteriosis

• Non-typhoidal Salmonella septicaemia

• Extrapulmonary tuberculosis

• Lymphoma

• Kaposi’s sarcoma

• HIV encephalopathy

• And/or performance scale 4: bed-ridden >50% of the day during last month.